After multiple clinical trials and one meta-analysis all demonstrating the efficacy of Avocado Soy Unsaponifiables (ASUs) treatment in joint pain, researchers moved on toward further testing ASU’s efficacy in larger groups of people. As a next step they conducted an observational study in routine medical practice for knee pain.

This study is a great follow up to the previous studies, in part because it involves far more people. But also it provides insight into real life situations as the participants basically receive their normal treatment from their primary doctor.

This study involved 6 months of 300mg of ASU treatment at 99 centers, involving a total of 4822 patients. As you can appreciate, these type of studies involve lots of more people and hence are far less likely to be biased.

The study focused on people with knee pain only. Participants assessed knee function and pain at the beginning and every two months until the conclusion.

The results of this study are very dramatic so lets go through them:
  • Significant improvement in function as a result of ASU treatment for 6 months.
  • Pain intensity decreased throughout the study as a result of ASU treatment.
  • Significant decrease in total NSAID and analgesic use as a result of the ASU.
  • No severe adverse events were associated with ASU treatment.

Overall, this study employing a massive number of subjects actually yielded some of the best results for ASU treatment found in the clinical literature.

The authors of the study concluded that ASU treatment “for 6 months showed gradual alleviation of joint pain, improvement of functional ability and a significant reduction of NSAIDs intake.” This study, in addition to the previous studies, all help to confirm that ASU treatment can reduce joint pain and increase joint function.

Gluszko P, Stasiek M. Symptom-modifying effects of oral avocado/soybean unsaponifiables in routine treatment of knee osteoarthritis in Poland. An open, prospective observational study of patients adherent to a 6-month treatment. Reumatologia/Rheumatology. 2016;5(5):217-226.